Orexin B 5mg (preorder)

Orexin B 5 mg ερευνητικής ποιότητας λυοφιλιωμένη σκόνη πεπτιδίου σε glass vial. This hypothalamic neuropeptide (also known as Hypocretin-2, Hcrt-2) is studied in experimental models of wakefulness, sleep–wake regulation, appetite control, energy balance και reward-related signaling.

Επισκόπηση έρευνας

Orexin B is an endogenous hypothalamic neuropeptide derived from the prepro-orexin precursor και is one of the two orexin/hypocretin ligκαιs alongside Orexin A. In experimental systems, Orexin B acts predominantly at the Orexin Receptor 2 (OX2R), where it serves as a potent agonist used to probe sleep–wake circuitry, arousal states, feeding behavior, energy homeostasis και reward-related pathways in vitro και in vivo research models.

Κύριοι τομείς έρευνας

• Ρύθμιση ύπνου–αφύπνισης και μοντέλα ναρκοληψίας: Used in laboratory studies investigating hypothalamic circuits that stabilize wakefulness, model narcolepsy-like phenotypes και dissect orexinergic contributions to sleep–wake transitions via OX2R signaling.
• Arousal, vigilance και stress-related arousal: Applied in experimental preparations to examine how orexinergic input modulates neuronal excitability, cortical activation και behavioral arousal under baseline και stress-related conditions.
• Appetite και energy homeostasis: Studied in preclinical feeding και metabolic models to explore the role of Orexin B in food intake, energy expenditure και integration of metabolic cues at the level of the hypothalamus.
• Κυκλώματα ανταμοιβής και κινήτρων: Employed to investigate orexinergic modulation of mesolimbic και mesocortical pathways, including reward-driven behaviors και motivational salience in rodent και in vitro systems.
• Συναπτική μετάδοση και νευρωνική πλαστικότητα: Used in electrophysiological και imaging studies to characterize how Orexin B influences glutamatergic signaling, neuronal firing patterns και plasticity in defined brain regions.