5-amino-1MQ 50mg – 30 κάψουλες

5-Amino-1MQ 50 mg — 30 ερευνητικές κάψουλες από του στόματος. 5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool και depletes tissue NAD⁺. In lκαιmark mouse studies, oral 5-amino-1MQ produced robust reductions σεdipocyte size, body fat και inflammatory adipokines while leaving food intake unchanged — pointing to a fundamentally novel “metabolic-rejuvenation” mechanism that operates entirely on the methylation–NAD axis. The 50 mg per-capsule format mirrors the daily oral dose used in published rodent pharmacology.

Επισκόπηση έρευνας

Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide και S-adenosyl-L-homocysteine [1]. In white adipose tissue of obese, insulin-resistant και aged mammals, NNMT is dramatically upregulated — και because it consumes both the universal methyl donor (SAM) και the NAD⁺ precursor (nicotinamide), its hyperactivity simultaneously depletes the cellular methylation reserve και the NAD-salvage pool [1,2]. 5-Amino-1MQ is the lead potent, selective small-molecule inhibitor of NNMT identified to date. Oral administration to diet-induced-obese mice for ~10 days reduces fat mass without altering food intake, decreases adipocyte size, restores insulin sensitivity, και increases adipose NAD⁺ και SAM levels [2]. In aged rodents, the same pharmacology has been extended to skeletal-muscle pathology, where it preserves muscle stem cell function και mitigates sarcopenia [3]. The molecule has become the canonical chemical probe for the entire NNMT–methylation–NAD axis και is the foundation for a growing field of “methylation-rejuvenation” research.

Κύριοι τομείς έρευνας

• NNMT enzymology και pharmacology — ο πρωτοπόρος εκλεκτικός αναστολέας NNMT μικρού μορίου, που χρησιμοποιήθηκε για την επικύρωση ολόκληρης της κατηγορίας στόχου [1,2].
• Adipose biology και obesity research — robust reductions σεdipocyte size και white-adipose mass in DIO mice without changes in food intake — a phenotype distinct from any approved anti-obesity mechanism [2].
• Cellular methylation και NAD⁺ pool dynamics — the only well-characterized chemical probe that simultaneously raises tissue NAD⁺ και SAM, enabling clean studies of the methyl-donor / NAD-salvage interface [1,2].
• Muscle aging και sarcopenia — preserves quiescent muscle-stem-cell pool και ameliorates aged-muscle dysfunction in rodent studies of sarcopenia [3].
• Metabolic-rejuvenation και longevity research — central to an emerging research framework that connects methylation tone, NAD⁺ availability και tissue-specific aging [1,3].

Βιβλιογραφία

1. Kraus D, Yang Q, Kong D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508(7495):258–262.
2. Neelakantan H, Vance V, Wetzel MD, et al. Selective και membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141–152.
3. Neelakantan H, Brightwell CR, Graber TG, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells και improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481–492.