Selank 10 mg research-grade lyophilized peptide powder in a glass vial. Selank is a synthetic heptapeptide analog of tuftsin studied in anxiety-like behaviour, stress-response, cognitive and neuroimmune research models.

Research Overview

Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin. In experimental systems it is used to explore neuropeptide signaling, anxiety-like behaviour, stress reactivity and interactions between the nervous and immune systems.

Primary Research Areas

• Anxiety & stress-response models: used in anxiolytic-like paradigms assessing behavioural responses and stress-induced changes in neurochemistry.
• Cognitive & memory research: studies of learning, memory consolidation and attention under baseline and stress conditions.
• Neuroimmune & inflammatory signaling: models investigating cytokine profiles, immune modulation and brain–immune crosstalk.
• Neurotransmitter & neurotrophic pathways: experimental work on monoamine balance, BDNF expression and synaptic plasticity markers.

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Methylene Blue 5 mg — 60 pharmaceutical-grade research capsules. Methylene blue holds a unique position in the history of pharmacology: it was the first synthetic drug ever used in humans (Ehrlich, 1891), the founding lead compound of every phenothiazine antipsychotic, the parent scaffold of every methylene-bridged tau aggregation inhibitor, and the gold-standard antidote for methemoglobinemia. In neuroscience, it has emerged over the past two decades as the most extensively characterized low-dose mitochondrial enhancer, with controlled human imaging studies demonstrating measurable effects on brain glucose metabolism, BOLD response and functional memory at doses an order of magnitude below the antimethemoglobinemia range. The 5 mg per-capsule format corresponds precisely to the low-dose nootropic and mitochondrial-enhancement window characterized in published clinical pharmacology.

Research Overview

Methylene blue (methylthioninium chloride) is a phenothiazine dye with an extraordinary range of well-characterized pharmacology, dose-dependent and frequently U-shaped [1]. At low concentrations (≤ 1 mg/kg), it acts as an alternative electron carrier in the mitochondrial electron transport chain — accepting electrons from NADH and donating them directly to cytochrome c — bypassing complex I/III blockades and increasing cellular ATP production and oxygen consumption rate [1,2]. At slightly higher concentrations it inhibits monoamine oxidase and tau aggregation, and at clinical-antidote concentrations it reduces methemoglobin to hemoglobin via the NADPH-dependent diaphorase pathway. Functional human imaging at 0.5–4 mg/kg shows increased cerebral glucose metabolism, BOLD response in memory-related circuits, and improved performance on declarative-memory tasks [3]. The molecule has a > 130-year clinical safety history, with the principal contraindications well-mapped (G6PD deficiency; concurrent serotonergic agents).

Primary Research Areas

• Mitochondrial bioenergetics and electron-transport bypass — the canonical small molecule for studying alternative-electron-carrier pharmacology and rescue of complex-I-deficient phenotypes [1,2].
• Cognitive and memory research — controlled human fMRI/PET studies show enhanced memory-task performance and increased brain glucose metabolism at low-dose ranges [3].
• Tauopathy and neurodegeneration — the parent scaffold for hydromethylthionine and a workhorse tool in tau-aggregation assays; investigated in AD, FTD and PSP models [1].
• Mood and psychiatric research — studied in bipolar depression and major depressive disorder, leveraging dose-dependent MAO-A inhibition and mitochondrial enhancement [1].
• Methemoglobinemia and oxidative-redox research — the gold-standard antidote and a robust probe of NADPH-diaphorase activity, G6PD-deficiency phenotypes and free-radical biology [1].

References

1. Tucker D, Lu Y, Zhang Q. From mitochondrial function to neuroprotection — an emerging role for methylene blue. Mol Neurobiol. 2018;55(6):5137–5153.
2. Atamna H, Nguyen A, Schultz C, et al. Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways. FASEB J. 2008;22(3):703–712.
3. Rodriguez P, Zhou W, Barrett DW, et al. Multimodal randomized functional MR imaging of the effects of methylene blue in the human brain. Radiology. 2016;281(2):516–526.

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