{"id":22979,"date":"2026-03-11T19:36:43","date_gmt":"2026-03-11T19:36:43","guid":{"rendered":"https:\/\/limitlesscyprus.com\/?post_type=product&p=22979"},"modified":"2026-07-20T22:54:38","modified_gmt":"2026-07-20T20:54:38","slug":"bpn14770-zatolmilast-5mg-60-tablets-el","status":"publish","type":"product","link":"https:\/\/limitlesscyprus.com\/el\/product\/bpn14770-zatolmilast-5mg-60-tablets-el\/","title":{"rendered":"BPN14770 (Zatolmilast) 5mg – 60 tablets"},"content":{"rendered":"
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BPN14770 \/ Zatolmilast 5 mg \u2014 60 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2.<\/strong> Zatolmilast (BPN14770) is the most clinically advanced selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) ever developed \u2014 \u03ba\u03b1\u03b9 arguably the most important new chemotype to emerge from intellectual-disability research in the past decade. Originally developed at Tetra Therapeutics (now part of Shionogi), BPN14770 has progressed through Phase II clinical trials in Fragile X syndrome with statistically significant improvements in cognitive composite scores, language \u03ba\u03b1\u03b9 daily-living function, \u03ba\u03b1\u03b9 is currently in Phase III development. Unlike older non-selective PDE4 inhibitors (rolipram, roflumilast), BPN14770’s allosteric mechanism preserves cAMP signaling under physiological conditions \u03ba\u03b1\u03b9 produces dose-dependent cognitive enhancement without the emetic \u03ba\u03b1\u03b9 tolerability ceiling that has limited the entire PDE4 class for decades.<\/p>\n

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\u039f\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1 IUPAC<\/div>\n
(R)-2-(4-((2-(3-chloro-4-fluorophenyl)-2H-tetrazol-5-yl)methoxy)-3-methoxyphenyl)acetamide (representative)<\/div>\n<\/div>\n
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1644648-69-2<\/div>\n<\/div>\n
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Zatolmilast; PDE4D allosteric inhibitor<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2<\/h3>\n

Phosphodiesterase 4D (PDE4D) is the predominant cAMP-degrading enzyme in mammalian brain, \u03ba\u03b1\u03b9 pharmacological inhibition of PDE4 has long been recognized as a potent strategy for enhancing memory \u03ba\u03b1\u03b9 synaptic plasticity \u2014 first demonstrated decades ago with the prototype molecule rolipram [1]. The clinical promise of PDE4 inhibition has, however, been blocked for forty years by the emetic \u03ba\u03b1\u03b9 GI side-effect profile shared by every non-selective PDE4 inhibitor, including the approved COPD drug roflumilast. BPN14770 is the first fundamentally new approach to this problem: it is a selective allosteric inhibitor of PDE4D that binds outside the catalytic site, producing partial \u2014 rather than complete \u2014 inhibition that preserves baseline cAMP signaling \u03ba\u03b1\u03b9 abolishes the dose-limiting emesis [1,2]. In a Phase II RCT \u03c3\u03b5dult males with Fragile X syndrome (Berry-Kravis et al., Nat Med 2021), 12-week BPN14770 produced statistically significant improvements in cognitive composite, language, \u03ba\u03b1\u03b9 daily-living function \u2014 the first ever positive cognitive-endpoint result \u03c3\u03b5ny Fragile X clinical trial [2]. The compound has now advanced into Phase III development \u03ba\u03b1\u03b9 is widely considered the most promising new pharmacological strategy for intellectual disability \u03ba\u03b1\u03b9 age-related cognitive decline [3].<\/p>\n

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\u039a\u03cd\u03c1\u03b9\u03bf\u03b9 \u03c4\u03bf\u03bc\u03b5\u03af\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2<\/h4>\n
    \n
  • \u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b1\u03bb\u03bb\u03bf\u03c3\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 PDE4D<\/strong> \u2014 the lead clinical-stage allosteric PDE4D inhibitor; the cleanest available chemical probe of partial-inhibition pharmacology in the cAMP pathway [1,2].<\/li>\n
  • \u0388\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b5\u03cd\u03b8\u03c1\u03b1\u03c5\u03c3\u03c4\u03bf\u03c5 \u03a7<\/strong> \u2014 the first molecule to produce a positive cognitive-endpoint signal \u03c3\u03b5ny Fragile X clinical trial \u2014 Phase II\/III development in Fragile X is ongoing [2].<\/li>\n
  • Memory \u03ba\u03b1\u03b9 synaptic plasticity<\/strong> \u2014 robust enhancement of LTP, working memory \u03ba\u03b1\u03b9 long-term memory consolidation in rodent models [1].<\/li>\n
  • Neurodevelopmental \u03ba\u03b1\u03b9 intellectual-disability research<\/strong> \u2014 \u03b4\u03b9\u03b5\u03c1\u03b5\u03c5\u03bd\u03ac\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03c3\u03c4\u03b1\u03b4\u03af\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b1\u03c0\u03b7\u03c1\u03af\u03b5\u03c2 \u03c0\u03ad\u03c1\u03b1\u03bd \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b5\u03cd\u03b8\u03c1\u03b1\u03c5\u03c3\u03c4\u03bf\u03c5 \u03a7 [3].<\/li>\n
  • \u0393\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ad\u03ba\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1<\/strong> \u2014 the partial-inhibition pharmacology \u03ba\u03b1\u03b9 tolerability profile open the PDE4 class to chronic cognitive-aging research for the first time [1,3].<\/li>\n<\/ul>\n

    <\/p>\n

    \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/h4>\n
      \n
    1. Gurney ME, Cogram P, Deacon RM, Rex C, Tranfaglia M. Multiple behavior phenotypes of the fragile-X syndrome mouse model respond to chronic inhibition of phosphodiesterase-4D (PDE4D). Sci Rep. 2017;7(1):14653.<\/li>\n
    2. Berry-Kravis EM, Harnett MD, Reines SA, et al. Inhibition of phosphodiesterase-4D \u03c3\u03b5dults with fragile X syndrome: a r\u03ba\u03b1\u03b9omized, placebo-controlled, Phase 2 clinical trial. Nat Med. 2021;27(5):862\u2013870.<\/li>\n
    3. Pelan SE, Anderson J, Beach J, et al. Selective inhibition of PDE4D for the treatment of fragile X syndrome \u03ba\u03b1\u03b9 other intellectual disabilities. Pharmacol Ther. 2023;241:108310.<\/li>\n<\/ol>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

      BPN14770 \/ Zatolmilast 5 mg \u2014 60 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2. Zatolmilast (BPN14770) is the most clinically advanced selective […]<\/p>\n","protected":false},"featured_media":4241,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_lb_product_label_url":"https:\/\/drive.google.com\/file\/d\/1Um-DKh1Nk4sGAh3qrxGUEYyQXptKZLjr\/view?usp=drive_link","_lb_product_label_size":"60x40","_lb_product_label_width":"60","_lb_product_label_height":"40"},"product_brand":[41],"product_cat":[1167,1158,1155],"product_tag":[],"class_list":["post-22979","product","type-product","status-publish","has-post-thumbnail","product_brand-limitlessbiochem","product_cat-1167","product_cat-1158","product_cat-1155","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","purchasable","product-type-simple","product-backorders-allowed"],"yoast_head":"\nBPN14770 Zatolmilast 5 mg \u2013 60 tablets | Limitless BioChem<\/title>\n<meta name=\"description\" content=\"Purchase BPN14770 (Zatolmilast) 5 mg tablets, 60 count. 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