{"id":22953,"date":"2026-03-30T15:31:19","date_gmt":"2026-03-30T15:31:19","guid":{"rendered":"https:\/\/limitlesscyprus.com\/?post_type=product&p=22953"},"modified":"2026-07-21T11:27:11","modified_gmt":"2026-07-21T09:27:11","slug":"nefiracetam-60-capsules-100mg-el","status":"publish","type":"product","link":"https:\/\/limitlesscyprus.com\/el\/product\/nefiracetam-60-capsules-100mg-el\/","title":{"rendered":"Nefiracetam – 60 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2 100mg"},"content":{"rendered":"
\n

<\/p>\n

Nefiracetam 100 mg \u2014 60 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2.<\/strong> Nefiracetam (DM-9384) is one of the most clinically advanced members of the entire racetam class \u2014 the subject of multi-thous\u03ba\u03b1\u03b9-patient Phase II\/III trials in post-stroke depression, post-stroke apathy \u03ba\u03b1\u03b9 Alzheimer’s disease at Mitsubishi Tanabe Pharma in Japan. Mechanistically, Nefiracetam pairs the canonical racetam cholinergic \u03ba\u03b1\u03b9 glutamatergic profile with two distinctive additional activities: GABA-A positive modulation that produces an anxiolytic phenotype not seen in piracetam or aniracetam, \u03ba\u03b1\u03b9 direct enhancement of L-type voltage-gated calcium channel activity \u2014 a mechanism uniquely positioned to influence post-ischemic synaptic plasticity. The 100 mg per-capsule dose corresponds to the principal Phase II\/III dose tier explored in the Japanese clinical-research program.<\/p>\n

<\/p>\n

\u0391\u03a0\u039f\u039a\u039b\u0395\u0399\u03a3\u03a4\u0399\u039a\u0391 \u0393\u0399\u0391 \u0395\u03a1\u0395\u03a5\u039d\u0397\u03a4\u0399\u039a\u0397 \u03a7\u03a1\u0397\u03a3\u0397<\/strong> \u00a0\u00b7\u00a0 \u0394\u03b5\u03bd \u03c0\u03c1\u03bf\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b7 \u03ae \u03ba\u03c4\u03b7\u03bd\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7. \u039c\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bb\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2.<\/div>\n

<\/p>\n

\n
\n
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\u039a\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1<\/div>\n
\u2265 99 % (HPLC) \u2014 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b1\u03c0\u03cc \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03bf \u03c6\u03bf\u03c1\u03ad\u03b1, CoA \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf<\/div>\n<\/div>\n
\n
\u039c\u03bf\u03c1\u03c6\u03ae<\/div>\n
\u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2<\/div>\n<\/div>\n
\n
\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf<\/div>\n
100 mg Nefiracetam \u03b1\u03bd\u03ac \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b1<\/div>\n<\/div>\n
\n
\u03a3\u03cd\u03bd\u03bf\u03bb\u03bf<\/div>\n
60 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2 per bottle (6 g total)<\/div>\n<\/div>\n
\n
\u03a3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/div>\n
\u03a3\u03c6\u03c1\u03b1\u03b3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c6\u03b9\u03ac\u03bb\u03b7 \u03bc\u03b5 \u03c0\u03ce\u03bc\u03b1 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b5\u03af\u03b1\u03c2<\/div>\n<\/div>\n
\n
\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/div>\n
\u0398\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03b4\u03c9\u03bc\u03b1\u03c4\u03af\u03bf\u03c5, \u03be\u03b7\u03c1\u03cc, \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03c9\u03c2<\/div>\n<\/div>\n
\n
\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c2<\/div>\n
C\u2081\u2084H\u2081\u2088N\u2082O\u2082<\/div>\n<\/div>\n
\n
\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2<\/div>\n
\u2248 246.31 g\u00b7mol\u207b\u00b9<\/div>\n<\/div>\n
\n
\u039f\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1 IUPAC<\/div>\n
N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide<\/div>\n<\/div>\n
\n
\u0391\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 CAS<\/div>\n
77191-36-7<\/div>\n<\/div>\n
\n
\u03a3\u03c5\u03bd\u03ce\u03bd\u03c5\u03bc\u03b1<\/div>\n
DM-9384; Translon; nefiracetam; N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide<\/div>\n<\/div>\n<\/div>\n<\/div>\n

<\/p>\n

\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2<\/h3>\n

Nefiracetam (DM-9384) is a 2-pyrrolidinone-derivative nootropic developed by Daiichi (later Mitsubishi Tanabe Pharma) in Japan in the 1980s, \u03ba\u03b1\u03b9 the only racetam to have advanced through multiple large-scale Phase II\/III clinical programs in Western-style indications [1]. In Phase II trials in post-stroke depression \u03ba\u03b1\u03b9 post-stroke apathy, Nefiracetam produced significant separation from placebo on Hamilton Depression \u03ba\u03b1\u03b9 apathy-scale endpoints \u2014 the latter being a particularly notable result because no approved drug specifically targets post-stroke apathy [1,2]. Mechanistically, Nefiracetam combines the canonical racetam pro-cholinergic profile (enhancement of high-affinity choline uptake \u03ba\u03b1\u03b9 acetylcholine release) \u03ba\u03b1\u03b9 pro-glutamatergic profile (NMDA-receptor potentiation \u03c3\u03b5 glycine-site-independent manner) with two distinctive additional mechanisms: positive allosteric modulation of GABA-A receptors (the basis of an anxiolytic phenotype absent in earlier racetams) \u03ba\u03b1\u03b9 direct enhancement of L-type voltage-gated calcium-channel activity in hippocampal pyramidal neurons [2,3]. This calcium-channel activity is unique within the racetam class \u03ba\u03b1\u03b9 provides a distinctive mechanistic angle for studying post-ischemic synaptic plasticity. The molecule retains the benign safety profile typical of the racetam class across multi-thous\u03ba\u03b1\u03b9 patient-years of clinical exposure.<\/p>\n

<\/p>\n

\u039a\u03cd\u03c1\u03b9\u03bf\u03b9 \u03c4\u03bf\u03bc\u03b5\u03af\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2<\/h4>\n
    \n
  • Post-stroke depression \u03ba\u03b1\u03b9 apathy research<\/strong> \u2014 the only racetam with Phase II\/III RCT evidence in these indications, \u03ba\u03b1\u03b9 one of the few molecules \u03c3\u03b5ny class with a documented signal on post-stroke apathy [1,2].<\/li>\n
  • Cholinergic \u03ba\u03b1\u03b9 glutamatergic pharmacology<\/strong> \u2014 enhancement of high-affinity choline uptake, ACh release \u03ba\u03b1\u03b9 NMDA-receptor potentiation \u2014 the canonical racetam profile [1,3].<\/li>\n
  • \u0398\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bb\u03bb\u03bf\u03c3\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 GABA-A<\/strong> \u2014 \u03bf \u03b1\u03b3\u03c7\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2 \u03b4\u03b9\u03b1\u03ba\u03c1\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03bd\u03b5\u03c6\u03b9\u03c1\u03b1\u03ba\u03b5\u03c4\u03ac\u03bc\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03c1\u03b1\u03ba\u03b5\u03c4\u03ac\u03bc\u03b5\u03c2 (\u03c0\u03b9\u03c1\u03b1\u03ba\u03b5\u03c4\u03ac\u03bc\u03b7, \u03b1\u03bd\u03b9\u03c1\u03b1\u03ba\u03b5\u03c4\u03ac\u03bc\u03b7) [2].<\/li>\n
  • \u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b4\u03b9\u03b1\u03cd\u03bb\u03c9\u03bd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03c4\u03cd\u03c0\u03bf\u03c5 L \u03c4\u03b1\u03c3\u03b5\u03bf\u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03c9\u03bd<\/strong> \u2014 \u03bf \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03b9\u03b1\u03cd\u03bb\u03c9\u03bd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03c1\u03b1\u03ba\u03b5\u03c4\u03b1\u03bc\u03ce\u03bd, \u03bc\u03b5 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03c5\u03bd\u03b1\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b9\u03c3\u03c7\u03b1\u03b9\u03bc\u03af\u03b1 [3].<\/li>\n
  • \u0388\u03c1\u03b5\u03c5\u03bd\u03b1 \u03bd\u03cc\u03c3\u03bf\u03c5 Alzheimer<\/strong> \u2014 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03a6\u03ac\u03c3\u03b7 II \u03c3\u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf Alzheimer\u00b7 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03bc\u03cc\u03c1\u03b9\u03bf \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03c9\u03bd \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd \u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7\u03c2 [1].<\/li>\n<\/ul>\n

    <\/p>\n

    \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/h4>\n
      \n
    1. Hwang Y, Lee Y, Han S, et al. Nefiracetam treatment improves cognitive impairment associated with chronic cerebral hypoperfusion. Neurosci Lett. 2009;464(1):35\u201339.<\/li>\n
    2. Robinson RG, Jorge RE, Clarence-Smith K, Starkstein S. Double-blind treatment of apathy in patients with poststroke depression using nefiracetam. J Neuropsychiatry Clin Neurosci. 2009;21(2):144\u2013151.<\/li>\n
    3. Yoshii M, Watabe S. Enhancement of neuronal calcium channel currents by the nootropic agent, nefiracetam (DM-9384), in NG108-15 cells. Brain Res. 1994;642(1-2):123\u2013131.<\/li>\n<\/ol>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

      Nefiracetam 100 mg \u2014 60 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2. Nefiracetam (DM-9384) is one of the most clinically advanced members […]<\/p>\n","protected":false},"featured_media":6630,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_lb_product_label_url":"https:\/\/drive.google.com\/file\/d\/1gqEv2gonF0t_9nKWgIny-7peXtdzQfS-\/view?usp=sharing","_lb_product_label_size":"150x50","_lb_product_label_width":"150","_lb_product_label_height":"50"},"product_brand":[],"product_cat":[1158,1162,1151],"product_tag":[],"class_list":["post-22953","product","type-product","status-publish","has-post-thumbnail","product_cat-1158","product_cat-1162","product_cat-1151","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","shipping-taxable","purchasable","product-type-simple","product-backorders-allowed"],"yoast_head":"\nNefiracetam - 60 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2 100mg - Limitless Cyprus<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/limitlesscyprus.com\/el\/product\/nefiracetam-60-capsules-100mg-el\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nefiracetam - 60 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2 100mg - Limitless Cyprus\" \/>\n<meta property=\"og:description\" content=\"Nefiracetam 100 mg \u2014 60 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2. 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