{"id":22897,"date":"2026-03-11T19:30:06","date_gmt":"2026-03-11T19:30:06","guid":{"rendered":"https:\/\/limitlesscyprus.com\/?post_type=product&p=22897"},"modified":"2026-07-28T03:58:31","modified_gmt":"2026-07-28T01:58:31","slug":"tb500-el","status":"publish","type":"product","link":"https:\/\/limitlesscyprus.com\/el\/product\/tb500-el\/","title":{"rendered":"TB-500 500mcg \u2014 40 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2"},"content":{"rendered":"
\n

<\/p>\n

\u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2 TB-500 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7.<\/strong> \u03a4\u03bf TB-500 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03b3\u03bf \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7 \u03b8\u03c5\u03bc\u03bf\u03c3\u03af\u03bd\u03b7 \u03b24 (T\u03b24) \u2014 \u03ad\u03bd\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf 43 \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03af\u03bd\u03b7, \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03ae \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03b9\u03c3\u03c4\u03cc \u03b8\u03b7\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b1\u03c4\u03b1\u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03c0\u03b9\u03bf \u03b5\u03ba\u03c4\u03b5\u03bd\u03ce\u03c2 \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b1\u03bd\u03b1\u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7\u03c2 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2. \u03a4\u03bf \u03b5\u03b3\u03b3\u03cd\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03b8\u03c1\u03b1\u03cd\u03c3\u03bc\u03b1, \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b9\u03c0\u03b1 17-23 (Ac-LKKTETQ-OH), \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af \u03c4\u03b7\u03bd \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b1\u03ba\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03bc\u03bf\u03c1\u03af\u03bf\u03c5 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c0\u03bf\u03bb\u03cd \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c5\u03ba\u03bf\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf. \u03a3\u03b5 \u03b4\u03cd\u03bf \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b5\u03c2 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03b9\u03ce\u03bd, \u03c4\u03bf TB-500 \/ T\u03b24 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2, \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2, \u03ba\u03b5\u03c1\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2, \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03ae\u03c2, \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03c5\u03bf\u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2, \u03bc\u03b5 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 II\/III \u03b3\u03b9\u03b1 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 (RGN-137), \u03be\u03b7\u03c1\u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03af\u03b1 (RGN-259, \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ae \u03ba\u03b5\u03c1\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03b3\u03bf\u03c1\u03ad\u03c2) \u03ba\u03b1\u03b9 \u03b5\u03c0\u03bf\u03cd\u03bb\u03c9\u03c3\u03b7 \u03c4\u03c1\u03b1\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd.<\/p>\n

<\/p>\n

\u0391\u03a0\u039f\u039a\u039b\u0395\u0399\u03a3\u03a4\u0399\u039a\u0391 \u0393\u0399\u0391 \u0395\u03a1\u0395\u03a5\u039d\u0397\u03a4\u0399\u039a\u0397 \u03a7\u03a1\u0397\u03a3\u0397<\/strong> \u00a0\u00b7\u00a0 \u0394\u03b5\u03bd \u03c0\u03c1\u03bf\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b7 \u03ae \u03ba\u03c4\u03b7\u03bd\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7. \u039c\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bb\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2.<\/div>\n

<\/p>\n

\n
\n
\n
\u039a\u03b1\u03b8\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1<\/div>\n
\u2265 98 % (HPLC) \u2014 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b1\u03c0\u03cc \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03bf \u03c6\u03bf\u03c1\u03ad\u03b1, CoA \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf<\/div>\n<\/div>\n
\n
\u039c\u03bf\u03c1\u03c6\u03ae<\/div>\n
\u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2<\/div>\n<\/div>\n
\n
\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf<\/div>\n
\u0394\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03b8\u03c1\u03b1\u03cd\u03c3\u03bc\u03b1 \u03b8\u03c5\u03bc\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 \u03b24 \/ TB-500 \u03b1\u03bd\u03ac \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b1 (\u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf CoA)<\/div>\n<\/div>\n
\n
\u03a3\u03cd\u03bd\u03bf\u03bb\u03bf<\/div>\n
40 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2 \u03b1\u03bd\u03ac \u03c6\u03b9\u03ac\u03bb\u03b7<\/div>\n<\/div>\n
\n
\u03a3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/div>\n
\u03a3\u03c6\u03c1\u03b1\u03b3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c6\u03b9\u03ac\u03bb\u03b7 \u03bc\u03b5 \u03c0\u03ce\u03bc\u03b1 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b5\u03af\u03b1\u03c2<\/div>\n<\/div>\n
\n
\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/div>\n
\u039a\u03b1\u03c4\u03ac \u03c0\u03c1\u03bf\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 2\u20138 \u00b0C, \u03c3\u03b5 \u03be\u03b7\u03c1\u03cc \u03bc\u03ad\u03c1\u03bf\u03c2, \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03c9\u03c2<\/div>\n<\/div>\n
\n
\u039c\u03b7\u03c4\u03c1\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf<\/div>\n
\u0398\u03c5\u03bc\u03bf\u03c3\u03af\u03bd\u03b7 \u03b24 (T\u03b24)\u00b7 43 \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03b1\u00b7 MW \u2248 4 963,4 g\u00b7mol\u207b\u00b9<\/div>\n<\/div>\n
\n
\u0394\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03b8\u03c1\u03b1\u03cd\u03c3\u03bc\u03b1<\/div>\n
Ac-LKKTETQ-OH (\u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b9\u03c0\u03b1 17-23 \u03c4\u03b7\u03c2 T\u03b24)\u00b7 MW \u2248 889,0 g\u00b7mol\u207b\u00b9<\/div>\n<\/div>\n
\n
\u0391\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 (parent)<\/div>\n
Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-OH<\/div>\n<\/div>\n
\n
\u0391\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 CAS<\/div>\n
77591-33-4 (\u0398\u03c5\u03bc\u03bf\u03c3\u03af\u03bd\u03b7 \u03b24)<\/div>\n<\/div>\n
\n
\u03a3\u03c5\u03bd\u03ce\u03bd\u03c5\u03bc\u03b1<\/div>\n
T\u03b24\u00b7 TMSB4X\u00b7 \u03b8\u03c5\u03bc\u03bf\u03c3\u03af\u03bd\u03b7 \u03b2\u03ae\u03c4\u03b1-4<\/div>\n<\/div>\n<\/div>\n<\/div>\n

<\/p>\n

\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2<\/h3>\n

\u0397 \u03b8\u03c5\u03bc\u03bf\u03c3\u03af\u03bd\u03b7 \u03b24 (T\u03b24) \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c0\u03b9\u03bf \u03ac\u03c6\u03b8\u03bf\u03bd\u03bf \u03bc\u03ad\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b2-\u03b8\u03c5\u03bc\u03bf\u03c3\u03b9\u03bd\u03ce\u03bd \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03c9\u03bd \u03b8\u03b7\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd, \u03cc\u03c0\u03bf\u03c5 \u03b7 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 \u03bc\u03bf\u03bd\u03bf\u03bc\u03b5\u03c1\u03bf\u03cd\u03c2 G-\u03b1\u03ba\u03c4\u03af\u03bd\u03b7\u03c2 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03b4\u03b5\u03be\u03b1\u03bc\u03b5\u03bd\u03ae \u03ad\u03c4\u03bf\u03b9\u03bc\u03b7 \u03c0\u03c1\u03bf\u03c2 \u03c0\u03bf\u03bb\u03c5\u03bc\u03b5\u03c1\u03b9\u03c3\u03bc\u03cc [1]. \u03a0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf, \u03b7 T\u03b24 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03c3\u03b5 \u03b4\u03cd\u03bf \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b5\u03c2 \u03c9\u03c2 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03cd \u03c6\u03ac\u03c3\u03bc\u03b1 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03b9\u03c3\u03c4\u03ce\u03bd: \u03c3\u03b5 \u03ba\u03b1\u03bb\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03b5\u03c0\u03b9\u03c4\u03b1\u03c7\u03cd\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03b5\u03bc\u03c6\u03c1\u03ac\u03ba\u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7\u00b7 \u03c0\u03c1\u03bf\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03cd\u03b3\u03ba\u03bb\u03b5\u03b9\u03c3\u03b7 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c4\u03c1\u03b1\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03bf\u03c5\u03bb\u03ad\u03c2\u00b7 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03bf\u03cd\u03bb\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03ba\u03b5\u03c1\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2\u00b7 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 VEGF\u00b7 \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03ae\u03c2 \u03ba\u03ac\u03ba\u03c9\u03c3\u03b7\u03c2 [1,2]. \u03a4\u03bf \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03b8\u03c1\u03b1\u03cd\u03c3\u03bc\u03b1 Ac-LKKTETQ \u2014 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b1\u03ba\u03c4\u03af\u03bd\u03b7\u03c2 \u2014 \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c7\u03b7\u03bc\u03b9\u03ba\u03ac \u03b1\u03c0\u03bb\u03bf\u03cd\u03c3\u03c4\u03b5\u03c1\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c5\u03ba\u03bf\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03bc\u03cc\u03c1\u03b9\u03bf [2]. \u0397 T\u03b24 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 II: RGN-137 \u03b3\u03b9\u03b1 \u03c0\u03bf\u03bc\u03c6\u03bf\u03bb\u03c5\u03b3\u03ce\u03b4\u03b7 \u03b5\u03c0\u03b9\u03b4\u03b5\u03c1\u03bc\u03cc\u03bb\u03c5\u03c3\u03b7, RGN-259 \u03b3\u03b9\u03b1 \u03be\u03b7\u03c1\u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ae \u03ba\u03b5\u03c1\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 (\u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03b3\u03bf\u03c1\u03ad\u03c2 \u03c9\u03c2 Regenetreat), \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03bf\u03cd\u03bb\u03c9\u03c3\u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03c9\u03bd \u03c4\u03c1\u03b1\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd [3].<\/p>\n

<\/p>\n

\u039a\u03cd\u03c1\u03b9\u03bf\u03b9 \u03c4\u03bf\u03bc\u03b5\u03af\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2<\/h4>\n
    \n
  • \u0395\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03b9\u03c3\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b5\u03c0\u03bf\u03cd\u03bb\u03c9\u03c3\u03b7 \u03c4\u03c1\u03b1\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong> \u2014 robust evidence of accelerated dermal, corneal \u03ba\u03b1\u03b9 epithelial closure across multiple injury models, with downstream signaling involving Akt, MAPK \u03ba\u03b1\u03b9 integrin pathways [1,2].<\/li>\n
  • \u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b3\u03ad\u03bd\u03bd\u03b7\u03c3\u03b7 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03ad\u03bc\u03c6\u03c1\u03b1\u03b3\u03bc\u03b1<\/strong> \u2014 T\u03b24 reactivates epicardial progenitor cells in the adult heart \u2014 a developmental population thought lost \u03c3\u03b5dulthood \u2014 providing a unique mechanistic angle for post-infarct repair research [1].<\/li>\n
  • \u0391\u03b3\u03b3\u03b5\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<\/strong> \u2014 modulates endothelial cell migration, capillary tube formation \u03ba\u03b1\u03b9 VEGF-mediated neovascularization in ex vivo \u03ba\u03b1\u03b9 in vivo models [2].<\/li>\n
  • \u039f\u03c6\u03b8\u03b1\u03bb\u03bc\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1<\/strong> \u2014 the corneal application has progressed furthest clinically; RGN-259 has been evaluated in multiple Phase II trials for dry eye \u03ba\u03b1\u03b9 neurotrophic keratopathy [3].<\/li>\n
  • \u039d\u03b5\u03c5\u03c1\u03bf\u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u039a\u039d\u03a3<\/strong> \u2014 characterized in models of stroke, traumatic brain injury \u03ba\u03b1\u03b9 multiple sclerosis with reproducible neuroprotective signals [2].<\/li>\n<\/ul>\n

    <\/p>\n

    \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/h4>\n
      \n
    1. Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin \u03b24: a multi-functional regenerative peptide. Basic properties \u03ba\u03b1\u03b9 clinical applications. Expert Opin Biol Ther. 2012;12(1):37\u201351.<\/li>\n
    2. Crockford D, Turjman N, Allan C, Angel J. Thymosin \u03b24: structure, function, \u03ba\u03b1\u03b9 biological properties supporting current \u03ba\u03b1\u03b9 future clinical applications. Ann N Y Acad Sci. 2010;1194:179\u2013189.<\/li>\n
    3. Sosne G, Kim C, Kleinman HK. Thymosin \u03b24 significantly reduces the signs of dryness \u03c3\u03b5 murine controlled adverse environment model of experimental dry eye. Expert Opin Biol Ther. 2015;15(suppl 1):S155\u2013S161.<\/li>\n<\/ol>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

      \u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2 TB-500 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7. \u03a4\u03bf TB-500 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03b3\u03bf \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7 \u03b8\u03c5\u03bc\u03bf\u03c3\u03af\u03bd\u03b7 \u03b24 (T\u03b24) […]<\/p>\n","protected":false},"featured_media":4098,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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